SEPT4 septin 4 [ Homo sapiens (human) ]
Gene ID: 5414, updated on 3-Apr-2016
Summary & Genomic context
Official Symbol
SEPT4provided by HGNC
Official Full Name
septin 4provided by HGNC
Primary source
HGNC:HGNC:9165
See related
Ensembl:ENSG00000108387; HPRD:04738; MIM:603696; Vega:OTTHUMG00000179243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H5; ARTS; MART; SEP4; CE5B3; PNUTL2; hucep-7; BRADEION; hCDCREL-2
Summary
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]
Orthologs
all
- Exon count:
- 18
| Annotation release | Status | Assembly | Chr | Location |
|---|
| 107 | current | GRCh38.p2 (GCF_000001405.28) | 17 | NC_000017.11 (58520250..58540818, complement) |
| 105 | previous assembly | GRCh37.p13 (GCF_000001405.25) | 17 | NC_000017.10 (56597611..56618179, complement) |
Chromosome 17 - NC_000017.11
